Sydney - Asian stocks fell on Wednesday as worries about waning global growth lifted safe-haven bonds and the yen, while shoving oil prices to their lowest in more than two years.
Government bonds were in big demand as investors wagered global inflation would continue to slow and even put off the day when US interest rates might rise.
Minutes of the Federal Reserve's last policy meeting are due later in the session and markets will be acutely sensitive to how the debate between hawks and doves on the committee was playing out.
In Asia, Japan's Topix shed 1.5% while the Nikkei dropped 1.4%.
MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.8%, while Australia's main index lost 0.7%.
China's markets were relatively steady as they returned from a week-long break, with Shanghai flat, but Hong Kong shed 0.7%.
A private survey of China's services sector showed growth eased a touch in September, but that only served to reinforce expectations of further stimulus measures by Beijing.
Stimulus is also very much on the cards in Europe after German industrial output suffered the biggest decline since the height of the financial crisis, piling pressure on the European Central Bank to be more urgent in its actions.
The IMF on Tuesday shaved its global growth forecast to 3.3% for this year, from 3.4%, warning of weakness in the eurozone, Japan and big emerging markets such as Brazil.
The IMF sees a 30% chance that the eur zone will fall into deflation and a nearly 40% risk it will slide into a recession over the next year. Data on Tuesday signalled Japan may already be in a mild recession.
"Weak numbers like the German production report fuel concern that ECB stimulus will be inadequate given the gloomier news," said Westpac analyst James Shugg.
"With the IMF waving its knife at its global growth forecasts, US markets couldn't avoid the downdraft either."
The Dow fell 1.6%, while the S&P 500 lost 1.51% and the Nasdaq 1.56%. The pan-European FTSEurofirst 300 also shed 1.5%.
What inflation?
Inflation swaps for the eurozone, which essentially show what investors think inflation will average over the next five years, have been in precipitous decline, touching a historic low of 1.89% this week.
This is one of ECB President Mario Draghi's favoured measures of inflation and its decline was a major reason the central bank launched a fresh stimulus package last month.
But the downdraft in inflation expectations is hardly confined to Europe. The US swaps rate has sunk to 2.62% , from 2.88% in August, even as the run of US economic data has been generally encouraging.
Likewise, longer-dated US Treasury yields have fallen noticeably as investors price in low inflation for longer.
Yields on 30-year bonds are now at their lowest since May 2013 at 3.05%, while their premium over two-year yields shrank to the smallest since late 2012.
Futures contracts predicting the course of the Fed funds rate have rallied hard in recent days as the market pushed out the date for the first hike.
They now show less than 50 basis points of tightening for 2015 and all of it in the second half of the year.
The fall in US yields dragged the dollar down from its recent highs. The dollar index was at 85.769, off a four-year peak of 86.746 hit on Friday.
The dollar initially slid as far as ¥107.76, before steadying at ¥108.23, still off a six-year high of ¥110.09 set a week ago. The euro edged up to $1.2646, and away from a two-year trough near $1.2500.
Commodities were under pressure on fears of weakening global demand. Brent crude oil fell 39 cents to $91.72 a barrel. It hit $91.25 on Monday, the lowest since June 2012.
US November crude eased another 38c to $88.47 a barrel, uncomfortably close to its recent trough of $88.18.