Johannesburg - President Jacob Zuma returned from Ghana on Wednesday after bilateral talks with Ghanaian President John Mahama, the presidency said.
"It was a very successful visit and it has yielded very important results which will see our bilateral relations moving to a higher level," Zuma said in a statement.
"We had high level bilateral talks with president Mahama and agreed on various issues, and we are pleased with the substantial progress that has been made in strengthening bilateral co-operation."
Zuma said agreements were signed which highlighted the level of co-operation between the two countries.
"We have agreed that these instruments should translate into concrete projects that will benefit our people and further promote our economic relations."
During his visit two memorandums of understanding - one on energy and another on transport related matters - were signed, as was an agreement on bilateral air services.
Zuma said South Africa and Ghana maintained strong and cordial relations.
Both presidents encouraged the business sector to take advantage of the agreements to enhance trade and investment.
Zuma arrived in Ghana on Monday night, accompanied by the ministers of international relations and co-operation, trade and industry, transport, energy, agriculture, forestry and fisheries, science and technology, and police. They were also accompanied by a business delegation.
In terms of trade and investments, Ghana represents a major export market for South African goods, said the presidency.
In 2012, South African exports to Ghana were estimated at R5bn and imports from Ghana at R1.9bn, the bulk of which was crude oil.
South Africa is the 14th largest investor in Ghana, with investments amounting to more than R64bn between 2003 and April 2013. More than 80 South African multinational and small-scale companies are registered in Ghana.