"The fuel, produced by Sasol's proprietary Coal to Liquids (CTL) process, is the world's only fully synthetic jet fuel to have received international approval as a commercial aviation turbine fuel," the compnay said in a statement.
The two-hour flight took off from Johannesburg to Cape Town.
"The approval by the international aviation fuel authorities of this product recognises the need to develop aviation fuel from feedstocks other than crude-oil, in order to meet the world's growing needs," Sasol chief executive Pat Davies said.
Sasol became the first company in the world to gain approval for the commercial use of a 50 percent synthetic jet fuel component, which was blended with petroleum kerosene.
To date, most of the aircraft leaving from South Africa's largest airport O.R Tambo International Airport in Johannesburg have flown using Sasol's semi-synthetic jet fuel, the company said.
"The fuel is fully fungible and aligned with the current aviation infrastructure through its compatibility with the existing engine requirements and can be used with conventional crude oil-derived jet fuelling systems," it said.
The company added that the approval process was stringent as the fuel had to meet with the strict specifications of global aviation authorities making the country a pioneer in green technology.